Bim phosphorylation
WebMar 24, 2016 · The isoform Bim EL is most highly expressed in most tissues, and the one exon only translated in the largest isoform Bim EL but not in Bim L or Bim S is the target of phosphorylation and ubiquitination in the Raf-ERK pathway (the degron comprises amino acids 91–100 in human Bim EL 22). WebMay 18, 2024 · One such protein, Bim, is known to stabilize Mcl-1, and Bim phosphorylation has been associated with increased Mcl-1 binding. Consequently, we investigated the potential impact of Bim …
Bim phosphorylation
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WebFeb 16, 2012 · This is surprising because BIM L lacks the serine residue equivalent to BIM EL S 69 and the ERK docking domain required for BIM EL phosphorylation. 46 Compared with BIM EL, there was a weaker correlation between levels of BIM L and ERK1/2 phosphorylation, which may reflect a requirement for additional intermediates to … WebSerine 88 Phosphorylation of the 8-kDa Dynein Light Chain 1 Is a Molecular Switch for Its Dimerization Status and Functions . × Close Log In. Log in with Facebook Log in with Google. or. Email. Password. Remember me on this computer. or reset password. Enter the email address you signed up with and we'll email you a reset link. ...
WebThis complex forms as a result of Bim-EL phosphorylation on serine 59, and thus Bim-EL cannot localize to the mitochondria and cause anoikis. These results reveal a novel mechanism that could be targeted with innovative therapeutics to induce anoikis in IBC cells. Publication types Research Support, Non-U.S. Gov't WebDec 9, 2009 · It upregulates Bim through its inhibition of phosphorylation by extracellular signal-regulated kinase (ERK). ERK-mediated phosphorylation targets Bim for ubiquitylation and induces proteasomal degradation ( 7, 19 ). TGF-β transcriptionally induces the mitogen-activated protein kinase (MAPK) phosphatase (MKP)2 through SMAD3.
WebInstead, BIM is a negative regulator of autophagy due to its ability to mislocalize BECLIN1 to the dynein light chain LC8 through a direct interaction that does not involve either the BIM or BECLIN1 BH3 domains (Luo and Rubinsztein, 2013). Starvation conditions leads to JNK-mediated phosphorylation of BIM and its release, together with BECLIN1 ... WebApr 5, 2024 · Because IHMT-MST1-39 targets MST1/2 in the Hippo signaling pathway, we next assessed the phosphorylation of MOB1 and LATS1 ... activates the mitochondrial-related cell death signaling in β cells through modulating the BH3-only protein member BIM and BAX. 10 Therefore, we investigated whether IHMT-MST1-39 was capable of …
Webregulating p-AKT by activating caspase-3 and that BIM mediates the level of AKT phosphorylation to determine the threshold for overcoming cisplatin resistance in ovarian cancer cells. Citation: Yuan Z, Wang F, Zhao Z, Zhao X, Qiu J, et al. (2011) BIM-Mediated AKT Phosphorylation Is a Key Modulator of Arsenic Trioxide-Induced Apoptosis in
WebJun 19, 2003 · Phosphorylation of BIM Does Not Alter Its Subcellular Localization or Integration into Mitochondrial Membranes The sequestration of cell death effectors within … chinese food near ucfWebApr 10, 2024 · FoxO3a phosphorylation was reported to cause transcriptional inhibition of apoptosis-related genes BIM and PUMA and subsequently inhibit cell apoptosis [17, 36, 37]. In the present study, we showed that Dan treatment was effective to activate the AKT/FoxO3a pathway and downregulated the pro-apoptotic genes BIM and PUMA in the … chinese food near usWebMay 11, 2024 · a Immunoprecipitation of endogenous HDAC1 and Western blot analysis to detect tyrosine phosphorylation in A549 and PC-9 cells with the indicated antibodies.b Predicted tyrosine phosphorylation ... grand marais mn city councilWebMay 18, 2024 · Bim phosphorylation mutations alter its ability to stabilize Mcl-1 in RPCI-WM1. (A) 30 μg of WCL from the indicated cell lines (phospho-mimetic, (left); unphosphorylateable, (right)) was subjected to … grand marais mn community educationWebMay 31, 2011 · Effect of AKT on BIM phosphorylation. Cells were metabolically labeled with [32 P] orthophosphoric acid and treated with ATO (2 µM) for 48 h, and BIM was immunoprecipitated by using an agarose-conjugated BIM antibody, then detection of phosphorylation of BIM. Phosphorylation of BIM was determined by autoradiography … grand marais mn harbor camWebJun 24, 2011 · Bim phosphorylation can decrease its stability or alter its interaction with other proteins to regulate apoptosis ( 21, 22 ). A number of studies have shown that Bim can be phosphorylated by ERK and that such phosphorylation leads to ubiquitination and subsequent degradation in the proteasome ( 16, 17, 21 ). grand marais mn city campgroundWebEnvironmental stress triggers Bim phosphorylation by JNK and results in its dissociation from the dynein complex and increased apoptotic activity. Survival factor induced ERK activation leads to phosphorylation of mouse Bim at Ser55, which inhibits its pro-apoptotic activity and association with Bax (10). O'Connor, L. et al. (1998) EMBO J 17 ... grand marais mn fisherman\u0027s picnic 2022