WebOct 1, 2024 · The authors concluded that intrathecal diamorphine 250 μg is a suitable alternative to morphine 100 μg (and presumably vice versa). Despite the paucity of studies directly comparing neuraxial morphine with diamorphine, current evidence suggests minimal difference in clinical efficacy and side-effects between the drugs in the … WebApr 11, 2024 · 6.Bruce McArthur — mall Santa. Day job: Mall Santa. Bruce McArthur was employed through an event management company as a mall Santa in the greater Toronto area. He pled guilty to the murder of eight men in 2024, leading to conviction without a trial for 25 years without parole.
Intrathecal diamorphine: a dose-response study - PubMed
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WebDiamorphine has a fast onset (<10 minutes) of analgesia and a long duration of action (10-20 hours intrathecal and epidural). It has a similar efficacy to fentanyl when used for intraoperative analgesia. It is commonly used for pain relief after caesarean delivery. Intrathecal opioids have been demonstrated to provide effective analgesia in the postoperative period. The principal advantage of intrathecal over systemic opioid techniques is that the former produces ‘segmental analgesia’ resulting in localized nociception without motor, sensory, autonomic, or systemic side … See more Intrathecal opioids bind to a family of G-protein-linked pre- and postsynaptic opioid receptors in Laminae I and II of the dorsal horn. Receptor activation leads to G-protein-mediated … See more Side-effects are mediated by opioid receptors. Segmental analgesia after intrathecal opioids administration should confer a lower side … See more The physicochemical properties of intrathecal opioids determine their onset time, duration of action, and potency. High lipid solubility and … See more The pharmacokinetics of intrathecal opioids are complex, follow a multi-compartmental model (Fig. 1), and are determined by the opioid physicochemical properties and the … See more WebOf these, 399 (83%) use intrathecal opioid routinely: 351/399 (88%) use diamorphine, 35 (8.8%) use morphine, 8 (2%) use fentanyl, and 7 (1.3%) use other drugs. The median … chrysanthemum fall