Irf8 promoter
WebNov 15, 2008 · IRF8 suppresses PU.1 expression. (A) IRF8 is present at the promoter region of PU.1 in vivo. ChIP analyses were performed with NFS-202 cells or purified spleen B cells. Protein-DNA complexes were immunoprecipitated by addition of antibody to IRF8 and analyzed by PCR for the presence of PU.1 promoter sequences.
Irf8 promoter
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WebApr 4, 2024 · IRF8, also known as interferon consensus sequence binding protein (ICSBP), is part of the IRF family of transcription factors that bind to specific DNA sequences named interferon-stimulated response elements (ISRE). WebIRF8 (interferon regulatory factor 8; OMIM 601565, Chr. 16) is a transcription factor that is …
WebJan 22, 2024 · Together these results suggest that IRF8 promotes EBV replication upon lytic induction. IRF8-dependent caspase activation is required for EBV reactivation As a transcription factor, IRF8 may also regulate EBV replication through … WebMar 21, 2024 · IRF8 (Interferon Regulatory Factor 8) is a Protein Coding gene. Diseases …
WebDec 11, 2024 · IRF8 is a suppressor of inflammation-induced colon cancer Summary and colitis-associated colon cancer, but it is also a risk locus associated with . The mechanism underlying the contrasting roles of IL-10 in inflammation and colon cancer is unknown. WebThe IRF8 promoter was found to interact with its flanking enhancers already at the CDP stage, and then more frequent interactions with its upstream and downstream sequences were found in pDC and cDC1, respectively. Interestingly, we identified a novel long non-coding RNA (lncRNA) transcribed from the +32 kb enhancer downstream of IRF8 ...
WebThe transcription factor interferon regulatory factor-8 (IRF8) is highly expressed in myeloid progenitors, while most myeloid leukemias show low or absent expression. Loss of IRF8 in mice leads to a myeloproliferative disorder, indicating a tumor-suppressive role of IRF8. The Wilms tumor gene 1 (WT1) protein represses the IRF8-promoter.
WebNov 26, 2024 · This sequence is strongly conserved in the IFIH1 promoters of eutherian mammals and in other distant species. Kinetic experiments, ... Among the nine IRFs, five (IRF1, IRF3, IRF7, IRF8, and IRF9) have been implicated as positive regulators of the transcription of type I IFN genes . In fact, the STAT1-dependent nature of IFN-α-, LPS-, ... how to submit maternity notification onlineWebMar 25, 2024 · IRF8 has also been found to be expressed and functional in non … reading lines rrWebMar 8, 2024 · IRF8 is a transcriptional regulator that is essential for the differentiation and function of monocytes and macrophages and thus may be involved in the regulation of macrophage phenotypes in SSc fibrosis. ... (rs11117422) interacts with the IRF8 promoter region (López-Isac et al., 2024. López-Isac E. Acosta-Herrera M. Kerick M. Assassi S. ... how to submit life certificate in sparshWebAug 8, 2007 · The GAPDH promoter was analysed as a negative control for IRF8. Data represent mean ± s.e.m. of quadruplicate real-time PCR. Full size image Next, we investigated the expression of CHRNA1 ex... how to submit maternity reimbursement onlineWebPromoters —Whether PU.1 and IRF8 bind to the C1qB promoter in vivo was examined by ChIP using macrophages. After formaldehyde fixation, nuclei were isolated from macrophages, sheared, and ... reading link challenge booksWebDec 11, 2024 · The Irf8 promoter CpG island is partially methylated in the human colon epithelial CCD841 cells but heavily methylated in human colon carcinoma HCT116 cells (Figure 3C). Analysis of The Cancer Genome Atlas (TCGA) datasets revealed the Irf8 promoter DNA has significantly higher methylation levels in tumors than in normal colon … reading lips 5eWebDec 12, 2024 · The Il9-luc and Irf8-luc luciferase constructs were obtained by inserting 2390 pb of Il9 and 1634 pb of Irf8 mouse promoters in the multicloning site of the pGl3 basic vector (Promega, Charboniere ... reading link