Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix loop helix … See more Myf5 is expressed in the dermomyotome of the early somites, pushing the myogenic precursors to undergo determination and differentiate into myoblasts. Specifically, it is first seen in the dorsomedial portion of the dermomyotome, … See more The regulation of Myf5 is dictated by a large number of enhancer elements that allow a complex system of regulation. Although most … See more • Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS (June 2005). "Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact". Journal of Cell … See more As for its clinical significance, the aberration of this transcription factor provides part of the mechanism for how hypoxia (lack of … See more WebDec 16, 2024 · These MRFs include myogenic differentiation 1 (MYOD1, also known as MyoD and MYF3), myogenic factor 5 (MYF5), myogenin (MYOG, also known as MYF4), and myogenic factor 6 (MYF6, also known as MRF4 and herculin). All four MRFs are specifically or preferentially expressed in skeletal muscle .
Myogenic Differentiation of Stem Cells for Skeletal Muscle ... - Hindawi
WebMyf5 (house mouse) Gene Target - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 503 National Center for Biotechnology Information 8600 Rockville Pike, Bethesda, MD, 20894 USA Contact Policies FOIA HHS Vulnerability Disclosure National Library of Medicine National Institutes of Health Web1 day ago · Indeed, satellite cell activation is caused by the induction of myogenic regulatory factors such as MYOD1 and myogenic factor 5 (MYF5). In contrast, differentiation involves the downregulation of PAX7, MYOG, and myosin heavy chain (MYHC) expression, followed by the fusion of differentiating myoblasts into myofibers. cahypo
Myogenic Factor 5 - an overview ScienceDirect Topics
WebFeb 5, 2024 · Transforming growth factor β (TGFβ) is a pluripotent cytokine and regulates a myriad of biological processes. It has been established that TGFβ potently inhibits skeletal muscle differentiation; however, the molecular mechanism is not clearly defined. Previously, we reported that inhibition of the TGFβ canonical pathway by an inhibitory Smad, Smad7, … WebNov 1, 2013 · Myf5 is the first MRF to be expressed, at E8 in the mouse ( 42 ). Transcripts are first detectable in the dermomyotome of the earliest somites, then in the newly formed myotome, followed by expression in the ventral dermomyotome and branchial arches ( 42 ). WebMay 23, 2011 · The determination and terminal differentiation of muscle cells is governed by four transcription factors known as myogenic regulatory factors (MRFs): myogenic factor 5 (MYF5), muscle-specific... cna employment seattle